Studies in the pulmonary circulation

Studies of the Pulmonary Circulation

The question of whether or not the blood-vessels of the pulmonary circulation are under the control of the central nervous system has been a subject for difference of opinion for many years. Several years ago I published ( I ) the results of some experiments bearing upon this problem, which led me to a belief in the existence of a vasomotor supply to the lesser circulation. Since then I have ca...

Studies on the peripheral pulmonary circulation time in COPD.

Diabetes and the pulmonary circulation.

DIABETES IS AN EPIDEMIC in the United States, affecting 8% of the population. The hallmark of diabetes is hyperglycemia due to either insulin deficiency or insulin resistance. Systemic vascular dysfunction is a central part of the pathophysiology of both type I insulin-dependent and type II non-insulin-dependent diabetes and involves both the microand macrocirculation (11). Coronary heart disea...

Fulvine and the pulmonary circulation.

The pyrrolizidine alkaloid, fulvine, is now accepted as a major cause of veno-occlusive disease of the liver in the West Indies, where it is ingested as a decoction of the plant Crotalaria fulva in bush tea. Fulvine is similar in chemical structure to monocrotaline, which is known to cause pulmonary hypertension in rats. Thirty young female rats were given a single dose of fulvine either by int...

Evolution and the pulmonary circulation.

We were sitting, I recall, in the canteen of the Medical School at Birmingham. It must have been 1958. I had just returned from a year and a half at the Bellevue Hospital, New York, my mind still reeling from the experience of working in the cardiopulmonary laboratory of Andre Cournand. Donald Heath had returned from the Mayo Clinic where he had coolly reshaped the face of pulmonary vascular pa...